Step onto the set of Grey's Anatomy, and you might think it's all medical drama, but behind the scenes, it's a whole other story filled with laughter, pranks, and genuine bonds.
Nothing beats the iconic duo of Ellen Pompeo and Patrick Dempsey—except maybe their pranks. One time, Dempsey filled Pompeo's surgical glove with jelly, leading to an unforgettable reaction.
Pompeo’s resounding laughter echoed through the studio, setting the tone for a light-hearted day of shooting.
Justin Chambers (Alex Karev) and T.R. Knight (George O'Malley) were notorious for their elaborate on-set pranks. From swapping scripts to tampering with props, the two actors kept everyone on their toes. “We had to watch our backs every day,” Knight once admitted, with a mischievous grin.

Amidst the pranks and laughter, heartfelt bonds formed.
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