In "Young Sheldon," people have been speculating about whether George really did cheat on Mary with neighbor Brenda, but now showrunner Steve Molaro has definitively confirmed that fact. The first time we knew George might be cheating was in an episode of The Big Bang Theory, when Sheldon explained the reason for knocking on the door three times.
George and his neighbor Brenda slowly grow closer over several episodes, and eventually Brenda asks George out. He agrees to go to her house for dinner, but before he can, he has a heart attack, which interrupts their relationship to develop further.
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