The Heartbreaking Denny Duquette
One of the most unforgettable patients is Denny Duquette, portrayed by Jeffrey Dean Morgan. His tragic love story with Izzie Stevens (Katherine Heigl) remains etched in fans' memories. Denny, suffering from heart failure, captures Izzie's heart, leading to one of the show's most poignant moments when she cuts his LVAD wire, hoping for a transplant.
The Mysterious Jane Doe
Elizabeth Reaser played Ava/Rebecca Pope, also known as Jane Doe, a patient found after a ferry accident.
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